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Article

A20 Inhibits Intraocular Inflammation in Mice by Regulating the Function of CD4+T Cells and RPE Cells.

Frontiers in immunology - 1 Jan 2020

Hu Jianping, Yi Shenglan, Wang Chaokui, Zhang Yiting, Tang Jihong, Huang Xinyue, Yang Lu, Yang Jinglu, Li Hong

Abstract excerpt

A20 is a negative regulator of inflammation and immunity and plays a role in several autoimmune and inflammatory diseases. Here, we demonstrate that A20 overexpression significantly ameliorates severity of EAU by inhibiting the infiltration of Th1 and Th17 cells, and by protecting integrity of the blood retinal barrier. In vitro studies showed that A20 silencing could promote CD4+T cells toward a Th1 and Th17...

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Source

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Identifiers

PMID: 33613524
DOI: 10.3389/fimmu.2020.603939
PMCID: PMC7890008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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