Article
Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 24 Sept 2024
Li Wanqian, He Siyuan, Tan Jun, Li Na, Zhao Chenyang, Wang Xiaotang, Zhang Zhi, Liu Jiangyi, Huang Jiaxing, Li Xingran, Zhou Qian, Hu Ke, Yang Peizeng, Hou Shengping
Abstract excerpt
Uveitis is a vision-threatening disease primarily driven by a dysregulated immune response, with retinal microglia playing a pivotal role in its progression. Although the transcription factor EGR2 is known to be closely associated with uveitis, including Vogt-Koyanagi-Harada disease and Behcet's disease, and is essential for maintaining the dynamic homeostasis of autoimmunity, its exact role in uveitis remains...
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