PTPN22 gene functional polymorphism (rs2476601) in older adults with frailty syndrome.

doi:10.1007/s11033-021-06212-4

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PTPN22 gene functional polymorphism (rs2476601) in older adults with frailty syndrome.

Molecular biology reports - 1 Feb 2021

Rabaneda-Bueno Rubén, Torres-Carrillo Norma, Ávila-Funes José Alberto, Gutiérrez-Robledo Luis Miguel, Pérez-Suárez Thalía Gabriela, Acosta José Luis, Torres-Castro Sara, Fletes-Rayas Ana Lilia, Gutierrez-Hurtado Itzae, Sandoval-Pinto Elena, Cremades Rosa, Torres-Carrillo Nora Magdalena

Abstract excerpt

The frailty syndrome is a common clinical marker of vulnerability in older adults conducive to an overall decline in inflammatory stress responsiveness; yet little is known about the genetic risk factors for frailty in elderly. Our aim was to investigate the association between the rs2476601 polymorphism in PTPN22 gene and susceptibility to frailty in Mexican older adults. Data included 630 subjects 70 and older...

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PMID: 33611779
DOI: 10.1007/s11033-021-06212-4

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