Prevalence of Homologous Recombination Pathway Gene Mutations in Melanoma: Rationale for a New Targeted Therapeutic Approach.

doi:10.1016/j.jid.2021.01.024

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Article

Prevalence of Homologous Recombination Pathway Gene Mutations in Melanoma: Rationale for a New Targeted Therapeutic Approach.

The Journal of investigative dermatology - 1 Aug 2021

Kim Kevin B, Soroceanu Liliana, de Semir David, Millis Sherri Z, Ross Jeffrey, Vosoughi Elham, Dar Altaf A, Nosrati Mehdi, Desprez Pierre-Yves, Ice Ryan, Chen Michelle, Chetal Kashish, Bhattacharjee Anukana, Moretto John, Leong Stanley P, Singer Mark I, Parrett Brian M, Minor David R, McAllister Sean, Miller James R, Salomonis Nathan, Kashani-Sabet Mohammed

Abstract excerpt

Homologous recombination DNA damage repair (HR-DDR) deficient patients with various solid tumors have been treated with PARP inhibitors. However, the clinical characteristics of patients with melanoma who have HR-DDR gene mutations and the consequences of PARP inhibition are poorly understood. We compared the commercially available next-generation sequencing data from 84 patients with melanomas from our...

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PMID: 33610559
DOI: 10.1016/j.jid.2021.01.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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