Article

PARP Inhibition as a Treatment Modality in Melanoma: What We Have Learned and What We Hope to Achieve

2024-12-04

Abstract excerpt

Genome integrity is a critical driver of cellular stability, and defects in the processes that maintain genome health are potent sources of cancer progression. Homologous recombination deficiency (HRD), which damages cells through absent or erroneous repair of double-stranded DNA breaks, is a prime example of such cellular dysfunction. Poly(ADP-ribose) polymerase (PARP) inhibitors exploit these aberrancies in the...

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Literature Corpus work: 863e0870-cfba-5ed7-b6a8-4bc5180fdb2e
DOI: 10.20944/preprints202412.0315.v1

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