Article
Mutational concordance analysis provides supportive information for double cancer diagnosis.
BMC cancer - 19 Feb 2021
Hatakeyama Keiichi, Nagashima Takeshi, Notsu Akifumi, Ohshima Keiichi, Ohnami Sumiko, Ohnami Shumpei, Shimoda Yuji, Naruoka Akane, Maruyama Koji, Iizuka Akira, Ashizawa Tadashi, Kenmotsu Hirotsugu, Mochizuki Tohru, Urakami Kenichi, Akiyama Yasuto, Yamaguchi Ken
Abstract excerpt
BACKGROUND: Mutation analysis using next-generation sequencing highlights the features of tumors with somatic alterations. However, the mutation profile of double cancer remains unclear. Here, we analyzed tumors derived from the same patient using whole exome sequencing (WES) to investigate the coherence of somatic mutations in double cancer. METHODS: First, the tumor mutational burden (TMB) was investigated...
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