Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas.

doi:10.1158/1078-0432.CCR-19-1266

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Article

Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2020

Capdevila Jaume, Arqués Oriol, Hernández Mora Jose Ramón, Matito Judit, Caratù Ginevra, Mancuso Francesco M, Landolfi Stefania, Barriuso Jorge, Jimenez-Fonseca Paula, Lopez Lopez Carlos, Garcia-Carbonero Rocio, Hernando Jorge, Matos Ignacio, Paolo Nuciforo, Hernández-Losa Javier, Esteller Manel, Martínez-Cardús Anna, Tabernero Josep, Vivancos Ana, Palmer Héctor G

Abstract excerpt

PURPOSE: The limited knowledge of the molecular alterations that characterize poorly differentiated neuroendocrine carcinomas has limited the clinical development of targeted agents directed to driver mutations. Here we aim to identify new molecular targets in colon neuroendocrine carcinomas (co-NEC) and proof the efficacy of matching drugs. EXPERIMENTAL DESIGN: We performed a multi-omic analysis of co-NEC to...

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PMID: 31672771
DOI: 10.1158/1078-0432.CCR-19-1266

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