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Article

Development of a rabbit model of Wiskott-Aldrich syndrome.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2021

Zhou Juanjuan, Yan Quanmei, Tang Chengcheng, Liao Yuan, Zhang Quanjun, Wang Xiaomin, Zhou Xiaoqing, Lai Liangxue, Zou Qingjian

Abstract excerpt

The Wiskott-Aldrich syndrome (WAS) is a severe recessive X-linked immunodeficiency resulting from loss-of-function mutations in the WAS gene. Mouse is the only mammalian model used for investigation of WAS pathogenesis. However, the mouse model does not accurately recapitulate WAS clinical phenotypes, thus, limiting its application in WAS clinical research. Herein, we report the generation of WAS knockout (KO)...

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Identifiers

PMID: 33236397
DOI: 10.1096/fj.202002118RR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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