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Article

Polygenic risk score for alcohol drinking behavior improves prediction of inflammatory bowel disease risk.

Human molecular genetics - 30 Apr 2021

Di Narzo Antonio F, Hart Amy, Kosoy Roman, Peters Lauren, Stojmirovic Aleksandar, Cheng Haoxiang, Zhang Zhongyang, Shan Mingxu, Cho Judy, Kasarskis Andrew, Argmann Carmen, Peter Inga, Schadt Eric E, Hao Ke

Abstract excerpt

Epidemiological studies have long recognized risky behaviors as potentially modifiable factors for the onset and flares of inflammatory bowel disease (IBD); yet, the underlying mechanisms are largely unknown. Recently, the genetic susceptibilities to cigarette smoking, alcohol and cannabis use [i.e. substance use (SU)] have been characterized by well-powered genome-wide association studies (GWASs). We aimed to...

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Identifiers

PMID: 33601420
DOI: 10.1093/hmg/ddab045
PMCID: PMC8599895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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