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Suppression of optineurin impairs the progression of hepatocellular carcinoma through regulating mitophagy

18 Feb 2021

Abstract excerpt

Autophagy removes damaged organelles to inhibit malignant transformation during tumor initiation. Once a cancer matures, it uses the autophagic pathway as an energy source. Optineurin (OPTN) is an autophagy adaptor protein that recruits microtubule-associated protein 1 light chain 3, an autophagosome marker, to the autophagosome. Despite studies of the relation between cancer progression and autophagy adaptor...

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PMID: 33600074
DOI: 10.1002/cam4.3519

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Suppression of optineurin impairs the progression of hepatocellular carcinoma through regulating mitophagyPMID 33600074Read ↗

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