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Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis

16 Jan 2025

Abstract excerpt

Mitochondrial homeostasis plays a crucial role in the pathogenesis of osteoarthritis (OA), a chronic musculoskeletal disorder characterized by articular cartilage degeneration and chondrocyte apoptosis. However, molecular mechanisms underlying the association between mitophagy and OA remain unclear. Here, we aimed to investigate the role of the autophagy receptor protein optineurin (OPTN) in OA, and explore the...

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PMID: 39820028
DOI: 10.1038/s42003-025-07541-x

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