Article
MARCH5 promotes autophagy through interaction with P62 leading to malignant progression of hepatocellular carcinoma
2023-10-17
Abstract excerpt
Dysregulated MARCH5 expression and impaired autophagy have been reported separately in some cancers. However, their relationship has not been explored in hepatocellular carcinoma (HCC). Here, we present evidence that MARCH5 promotes autophagy by interacting with p62 to mediate its ubiquitylation for subsequent degradation and thus contributes to cancer proliferation, invasion, and migratory migration. Our clinical...
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Identifiers and source
- Literature Corpus work
- aad6a62f-931d-5eac-b0e5-8b755cbfa32f
- DOI
- 10.21203/rs.3.rs-3416817/v1