Article
In vivo characterization of physiological and metabolic changes related to isocitrate dehydrogenase 1 mutation expcression by multiparametric MRI and MRS in a rat model with orthotopically grafted human-derived glioblastoma cell lines.
NMR in biomedicine - 1 Jun 2021
Clément Alexandra, Doyen Matthieu, Fauvelle Florence, Hossu Gabriela, Chen Bailiang, Barberi-Heyob Muriel, Hirtz Alex, Stupar Vasile, Lamiral Zohra, Pouget Celso, Gauchotte Guillaume, Karcher Gilles, Beaumont Marine, Verger Antoine, Lemasson Benjamin
Abstract excerpt
The physiological mechanism induced by the isocitrate dehydrogenase 1 (IDH1) mutation, associated with better treatment response in gliomas, remains unknown. The aim of this preclinical study was to characterize the IDH1 mutation through in vivo multiparametric MRI and MRS. Multiparametric MRI, including the measurement of blood flow, vascularity, oxygenation, permeability, and in vivo MRS, was performed on a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.