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Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer

16 Feb 2021

Abstract excerpt

BACKGROUND: Neurotrophic tropomyosin receptor kinases (NTRKs) are a gene family function as oncogene or tumor suppressor gene in distinct cancers. We aimed to investigate the methylation and expression profiles and prognostic value of NTRKs gene in colorectal cancer (CRC). METHODS: An analysis of DNA methylation and expression profiles in CRC patients was performed to explore the critical methylations within...

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PMID: 33593392
DOI: 10.1186/s12967-021-02740-6

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