Article
Structural brain measures linked to clinical phenotypes in major depression replicate across clinical centres.
Molecular psychiatry - 1 Jul 2021
Yu Meichen, Cullen Nicholas, Linn Kristin A, Oathes Desmond J, Seok Darsol, Cook Philip A, Duprat Romain, Aselcioglu Irem, Moore Tyler M, Davatzikos Christos, Oquendo Maria A, Weissman Myrna M, Shinohara Russell T, Sheline Yvette I
Abstract excerpt
Abnormalities in brain structural measures, such as cortical thickness and subcortical volumes, are observed in patients with major depressive disorder (MDD) who also often show heterogeneous clinical features. This study seeks to identify the multivariate associations between structural phenotypes and specific clinical symptoms, a novel area of investigation. T1-weighted magnetic resonance imaging measures were...
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