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A small-molecular inhibitor against Proteus mirabilis urease to treat catheter-associated urinary tract infections

12 Feb 2021

Abstract excerpt

Infection and blockage of indwelling urinary catheters is significant owing to its high incidence rate and severe medical consequences. Bacterial enzymes are employed as targets for small molecular intervention in human bacterial infections. Urease is a metalloenzyme known to play a crucial role in the pathogenesis and virulence of catheter-associated Proteus mirabilis infection. Targeting urease as a therapeutic...

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PMID: 33580163
DOI: 10.1038/s41598-021-83257-2

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