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Article

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

12 Feb 2021

Abstract excerpt

Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 (PRMT5) has recently emerged as a promising target in GBM. Using two orthogonal-acting inhibitors of PRMT5 (GSK591 or LLY-283), we show that pharmacological inhibition of PRMT5 suppresses the growth of a cohort of 46 patient-derived GBM stem...

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PMID: 33579912
DOI: 10.1038/s41467-021-21204-5

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