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Article

Protection of nuclear DNA by lifespan-extending compounds in the yeast Saccharomyces cerevisiae.

Mutation research - 1 Jan 2000

Su Wei-Hsuan, Chan Christelle E T, Lian Ting, Biju Mareena, Miura Ayaka, Alkhafaji Sarah A, Do Kelton K, Latifi Brandon, Nguyen Thi T, Schriner Samuel E

Abstract excerpt

DNA damage has been hypothesized to be a driving force of the aging process. At the same time, there exists multiple compounds that can extend lifespan in model organisms, such as yeast, worms, flies, and mice. One possible mechanism of action for these compounds is a protective effect against DNA damage. We investigated whether five of these lifespan-extending compounds, dinitrophenol, metformin, rapamycin,...

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Identifiers

PMID: 33578051
DOI: 10.1016/j.mrfmmm.2021.111738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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