Article
Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes.
Clinical and experimental nephrology - 1 Jun 2011
Maeda Shiro, Koya Daisuke, Araki Shin-Ichi, Babazono Tetsuya, Umezono Tomoya, Toyoda Masao, Kawai Koichi, Imanishi Masahito, Uzu Takashi, Suzuki Daisuke, Maegawa Hiroshi, Kashiwagi Atsunori, Iwamoto Yasuhiko, Nakamura Yusuke
Abstract excerpt
BACKGROUND: Sirtuin is a member of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, and has been reported to play a pivotal role in energy expenditure, mitochondrial function and pathogenesis of metabolic diseases, including aging kidneys. In this study, we focused on the genes encoding sirtuin families, and examined the association between single nucleotide polymorphisms (SNPs) within genes...
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