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Article

SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy.

Scientific reports - 31 Aug 2017

Zhao Yanyan, Wei Junfang, Hou Xuefeng, Liu Huimiao, Guo Feng, Zhou Yingni, Zhang Yuanyuan, Qu Yunhui, Gu Junfei, Zhou Yuanli, Jia Xiaobin, Qin Guijun, Feng Liang

Abstract excerpt

SIRT1 and FOXO1 play an important role in the pathogenesis of diabetic nephropathy (DN). However, the association between genetic polymorphisms and susceptibility to type 2 DN (T2DN) has not been explored. In this study, a total of 1066 patients with type 2 diabetes mellitus (T2DM) (413 without and 653 with DN) were enrolled. The genotypes of three htSNPs (rs3818292, rs4746720, rs10823108) within SIRT1 and two...

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Topics

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Share to Diabetic Nephropathies
Share to Environment
Share to Epistasis, Genetic
Share to Forkhead Box Protein O1
Share to Genetic Association Studies
Share to Genetic Loci
Share to Odds Ratio
Share to Sirtuin 1

Source

Open in PubMed Open full text

Identifiers

PMID: 28860538
DOI: 10.1038/s41598-017-10612-7
PMCID: PMC5579017

Genes

FOXO1
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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