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Article

Rare variants in MTHFR predispose to occurrence and recurrence of pulmonary embolism.

International journal of cardiology - 15 May 2021

Tan Jiang-Shan, Yan Xin-Xin, Wu Yan, Gao Xin, Xu Xi-Qi, Jiang Xin, Jia Lei, Hu Song, Hua Lu, Wang Xiao-Jian

Abstract excerpt

BACKGROUND: Rare genetic variants play a critical role in unprovoked pulmonary embolism (PE). However, the known risk genes only account a small proportion of patients with PE. The objective of this study was to investigate the relationship between the rare variants of gene encoding methylenetetrahydrofolate reductase (MTHFR) and the initiation and long-term clinical outcomes of PE. METHODS: The rare variants of...

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Identifiers

PMID: 33571559
DOI: 10.1016/j.ijcard.2021.01.073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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