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Article

Polymorphisms C677T and A1298C of MTHFR Gene: Homocysteine Levels and Prothrombotic Biomarkers in Coronary and Pulmonary Thromboembolic Disease.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Jan 2000

Lupi-Herrera Eulo, Soto-López María Elena, Lugo-Dimas Antonio de Jesús, Núñez-Martínez Marcela Elizabeth, Gamboa Ricardo, Huesca-Gómez Claudia, Sierra-Galán Lilia Mercedes, Guarner-Lans Verónica

Abstract excerpt

The activity of the enzyme methylenetetrahydrofolate reductase (MTHFR) determines homocysteine (Hcy) levels, and polymorphisms in its gene affect the activity of the enzyme. Changes in the enzyme's activity may lead to a higher susceptibility to develop arterial and venous thromboembolic disease. The aim was to analyze the relationship between the C677T and A1298C polymorphisms of MTHFR, Hcy levels, and...

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Identifiers

PMID: 29916259
DOI: 10.1177/1076029618780344
PMCID: PMC6714945

Genes

MTHFR

Provenance

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