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Article

Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors.

Blood advances - 12 Jan 2021

Shanmugam Vignesh, Craig Jeffrey W, Hilton Laura K, Nguyen Matthew H, Rushton Christopher K, Fahimdanesh Kian, Lovitch Scott, Ferland Ben, Scott David W, Aster Jon C

Abstract excerpt

Notch receptors participate in a signaling pathway in which ligand-induced proteolysis frees the Notch intracellular domain (NICD), allowing it to translocate to the nucleus, form a transcription complex, and induce target gene expression. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), splenic marginal zone B-cell lymphoma (SMZL), and distinct subsets of diffuse large B-cell lymphoma (DLBCL)...

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Share to B-Lymphocytes
Share to Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

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Source

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Identifiers

PMID: 33570635
DOI: 10.1182/bloodadvances.2020002995
PMCID: PMC7805321

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