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microRNA-483 Protects Pancreatic β-Cells by Targeting ALDH1A3

10 Feb 2021

Abstract excerpt

Pancreatic β-cell dysfunction is central to the development and progression of type 2 diabetes. Dysregulation of microRNAs (miRNAs) has been associated with pancreatic islet dysfunction in type 2 diabetes. Previous study has shown that miR-483 is expressed relatively higher in β-cells than in α-cells. To explore the physiological function of miR-483, we generated a β-cell-specific knockout mouse model of miR-483....

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PMID: 33564883
DOI: 10.1210/endocr/bqab031

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