Article

Reduced miR-184-3p expression occurring in Type 2 diabetic pancreatic islets protects β-cells from lipotoxic and proinflammatory apoptosis via a CRTC1-dependent mechanism

2021-01-04

Abstract excerpt

Loss of functional β-cell mass in Type 2 diabetes (T2D) involves molecular mechanisms including β-cell apoptosis, dysfunction, and/or dedifferentiation. MicroRNA miR-184-3p has been demonstrated to be involved in multiple β-cell functions including insulin secretion, proliferation and survival. However, downstream targets and upstream regulators of miR-184-3p have not yet been fully elucidated. Here, we showed tha...

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Literature Corpus work: c9509910-2262-540c-9304-257e57807326
DOI: 10.1101/2021.01.04.425234

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Reduced miR-184-3p expression occurring in Type 2 diabetic pancreatic islets protects β-cells from lipotoxic and proinflammatory apoptosis via a CRTC1-dependent mechanismDOI 10.1101/2021.01.04.425234Read

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