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Article

The KINGS Ins2 +/G32S Mouse: A Novel Model of β-Cell Endoplasmic Reticulum Stress and Human Diabetes.

Diabetes - 1 Dec 2020

Austin Amazon L F, Daniels Gatward Lydia F, Cnop Miriam, Santos Gabriel, Andersson David, Sharp Sally, Gentry Clive, Bevan Stuart, Jones Peter M, King Aileen J F

Abstract excerpt

Animal models are important tools in diabetes research because ethical and logistical constraints limit access to human tissue. β-Cell dysfunction is a common contributor to the pathogenesis of most types of diabetes. Spontaneous hyperglycemia was developed in a colony of C57BL/6J mice at King's College London (KCL). Sequencing identified a mutation in the Ins2 gene, causing a glycine-to-serine substitution at...

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Identifiers

PMID: 32994272
DOI: 10.2337/db20-0570
PMCID: PMC7679781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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