The variant T allele of PvuII in ESR1 gene is a prognostic marker in early breast cancer survival.

doi:10.1038/s41598-021-82002-z

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The variant T allele of PvuII in ESR1 gene is a prognostic marker in early breast cancer survival.

Scientific reports - 5 Feb 2021

Houtsma Danny, de Groot Stefanie, Baak-Pablo Renee, Kranenbarg Elma Meershoek-Klein, Seynaeve Caroline M, van de Velde Cornelis J H, Böhringer Stefan, Kroep Judith R, Guchelaar Henk -Jan, Gelderblom Hans

Abstract excerpt

The PvuII (rs2234693) Single Nucleotide Polymorphism (SNP) in the gene coding for the estrogen receptor-1 (ESR1), has been found associated with outcome in tamoxifen treated patients with early hormone-receptor positive breast cancer. However, it remains unclear whether this SNP is a predictive marker for tamoxifen efficacy or a prognostic marker for breast cancer outcome. The aim of this study was to examine the...

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PMID: 33547330
DOI: 10.1038/s41598-021-82002-z
PMCID: PMC7864972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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