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Article

The Role of ESR1 Gene Polymorphic Markers in the Development of Breast Cancer and Resistance to Tamoxifen Therapy.

Bulletin of experimental biology and medicine - 1 Jan 2021

Lukina S S, Burdennyy A M, Zavarykina T M, Riabchikov D A, Kazubskaya T P, Kruglova M P, Loginov V I

Abstract excerpt

We studied the effect of functionally significant polymorphic markers of the ESR1 gene on the risk of breast cancer, tamoxifen resistance, and survival of patients with this type of cancer. The study included 239 primary breast cancer patients without distant metastases. The analysis of genotype frequency distribution for the studied ESR1 gene polymorphic markers showed the association of the rs2228480 and...

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PMID: 33452979
DOI: 10.1007/s10517-021-05065-y

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