Article
ESR1 and PGR polymorphisms are associated with estrogen and progesterone receptor expression in breast tumors.
Physiological genomics - 1 Sept 2016
Hertz Daniel L, Henry N Lynn, Kidwell Kelley M, Thomas Dafydd, Goddard Audrey, Azzouz Faouzi, Speth Kelly, Li Lang, Banerjee Mousumi, Thibert Jacklyn N, Kleer Celina G, Stearns Vered, Hayes Daniel F, Skaar Todd C, Rae James M
Abstract excerpt
Hormone receptor-positive (HR+) breast cancers express the estrogen (ERα) and/or progesterone (PgR) receptors. Inherited single nucleotide polymorphisms (SNPs) in ESR1, the gene encoding ERα, have been reported to predict tamoxifen effectiveness. We hypothesized that these associations could be attributed to altered tumor gene/protein expression of ESR1/ERα and that SNPs in the PGR gene predict tumor PGR/PgR...
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