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Article

Two mechanisms drive pronuclear migration in mouse zygotes

5 Feb 2021

Abstract excerpt

A new life begins with the unification of the maternal and paternal chromosomes upon fertilization. The parental chromosomes first become enclosed in two separate pronuclei near the surface of the fertilized egg. The mechanisms that then move the pronuclei inwards for their unification are only poorly understood in mammals. Here, we report two mechanisms that act in concert to unite the parental genomes in...

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PMID: 33547291
DOI: 10.1038/s41467-021-21020-x

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