Article
Asymmetric Reprogramming Capacity of Parental Pronuclei in Mouse Zygotes
1 Mar 2014
Abstract excerpt
It has been demonstrated that reprogramming factors are sequestered in the pronuclei of zygotes after fertilization, because zygotes enucleated at the M phase instead of interphase of the first mitosis can support the development of cloned embryos. However, the contribution of the parental pronucleus derived from either the sperm or the oocyte in reprogramming remains elusive. Here, we demonstrate that the...
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