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Article

Self-assembled VEGF-R2 targeting DNA aptamer-collagen fibers stimulate an angiogenic-like endothelial cell phenotype.

Materials science & engineering. C, Materials for biological applications - 1 Jan 2021

James Bryan D, Allen Josephine B

Abstract excerpt

Vascularization of engineered tissue is one of the hallmark challenges of tissue engineering. Leveraging self-assembled nucleic acid-collagen complexes (NACCs), we mixed a VEGF-R2 targeting aptamer or its receptor agonist divalent assembly with type I collagen to assemble NACC microfibers. Human umbilical vein endothelial cells (HUVECs) quickly remodeled these fibers into tubulogenic-like structures over 48 h....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33545845
DOI: 10.1016/j.msec.2020.111683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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