Article
Copolymer-Mediated Cell Aggregation Promotes a Proangiogenic Stem Cell Phenotype In Vitro and In Vivo.
Advanced healthcare materials - 1 Nov 2016
Crowder Spencer W, Balikov Daniel A, Boire Timothy C, McCormack Devin, Lee Jung Bok, Gupta Mukesh K, Skala Melissa C, Sung Hak-Joon
Abstract excerpt
Material-induced cell aggregation drives a proangiogenic expression profile. Copolymer substrates containing cell-repellent and cell-adhesive domains force the aggregation of human mesenchymal stem cells, which results in enhanced tubulogenesis in vitro and stabilization of vasculature in vivo. These findings can be used to design instructive biomaterial scaffolds for clinical use.
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