Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle-intervention in germline BRCA1/2 gene mutation carriers.

doi:10.1007/s10549-020-06070-x

Article

Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle-intervention in germline BRCA1/2 gene mutation carriers.

Breast cancer research and treatment - 1 Apr 2021

Grill Sabine, Yahiaoui-Doktor Maryam, Basrai Maryam, Struck Joachim, Schulte Janin, Berling-Ernst Anika, Engel Christoph, Ullrich Mirjam, Lammert Jacqueline, Bischoff Stephan C, Schmidt Thorsten, Niederberger Uwe, Chronas Dimitrios, Rhiem Kerstin, Schmutzler Rita, Halle Martin, Kiechle Marion

Abstract excerpt

BACKGROUND: Germline BRCA1/2 mutation carriers (gBMC) face increased cancer risks that are modulated via non-genetic lifestyle factors whose underlying molecular mechanisms are unknown. The peptides Neurotensin (NT) and Enkephalin (ENK)-involved in tumorigenesis and obesity-related diseases-are of interest. We wanted to know whether these biomarkers differ between gBMC and women from the general population and...

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