Article
Neurotensin up-regulation is associated with advanced fibrosis and hepatocellular carcinoma in patients with MAFLD.
Biochimica et biophysica acta. Molecular and cell biology of lipids - 1 Oct 2020
Dongiovanni Paola, Meroni Marica, Petta Salvatore, Longo Miriam, Alisi Anna, Soardo Giorgio, Valenti Luca, Miele Luca, Grimaudo Stefania, Pennisi Grazia, Antonio Grieco, Consonni Dario, Fargion Silvia, Fracanzani Anna Ludovica
Abstract excerpt
BACKGROUND & AIMS: Neurotensin (NTS), a 13-aminoacid peptide localized in central nervous system and gastrointestinal tract, is involved in lipid metabolism and promotes various cancers onset mainly by binding to neurotensin receptor 1 (NTSR1). Increased plasma levels of pro-NTS, the stable NTS precursor, have been associated with type 2 diabetes (T2D), cardiovascular diseases and metabolic associated fatty liver...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.