Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic dissection of serum pro-neurotensin suggests potential causal impact on brain structure.

EBioMedicine - 1 Feb 2026

Breitfeld Jana, Horn Katrin, Velluva Akhil, Beyer Frauke, Pott Janne, Baber Ronny, Stumvoll Michael, Le Duc Diana, Witte Veronica, Giontella Alice, Melander Olle, Kovacs Peter, Scholz Markus, Tönjes Anke

Abstract excerpt

BACKGROUND: Pro-neurotensin (pro-NT) is the stable circulating precursor of neurotensin (NT), a neuropeptide expressed mainly in the central nervous system and small intestine that regulates key physiological processes like fatty acid absorption in the gut and suppresses appetite via central mechanisms. Studies in NT-deficient mice and humans implicate NT in obesity and insulin resistance, highlighting its role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Magnetic Resonance Imaging

Share to Obesity

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41520650
DOI: 10.1016/j.ebiom.2025.106105
PMCID: PMC12818281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Genetic dissection of serum pro-neurotensin suggests potential causal impact on brain structure.PMID 41520650Read ↗

Neurotensin up-regulation is associated with advanced fibrosis and hepatocellular carcinoma in patients with MAFLD.Semantic proximity Read ↗

Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease.Semantic proximity Read ↗

Obesity gene NEGR1 associated with white matter integrity in healthy young adults.Semantic proximity Read ↗

Effects of norepinephrine transporter gene variants on NET binding in ADHD and healthy controls investigated by PET.Semantic proximity Read ↗

Interplay of Large Neutral Amino Acids, Metabolic Syndrome, and Apolipoprotein E ε4 on Brain Integrity at Midlife.Semantic proximity Read ↗

Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community: The Framingham Heart Study.Semantic proximity Read ↗

Association of Neurotensin receptor 1 gene polymorphisms with processing speed in healthy Chinese-Han subjects.Semantic proximity Read ↗

Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle-intervention in germline BRCA1/2 gene mutation carriers.Semantic proximity Read ↗

Increased meso-striatal connectivity mediates trait impulsivity in FTO variant carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.