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Article

RAC1 controls progressive movement and competitiveness of mammalian spermatozoa.

PLoS genetics - 1 Feb 2021

Amaral Alexandra, Herrmann Bernhard G

Abstract excerpt

Mammalian spermatozoa employ calcium (Ca2+) and cyclic adenosine monophosphate (cAMP) signaling in generating flagellar beat. However, how sperm direct their movement towards the egg cells has remained elusive. Here we show that the Rho small G protein RAC1 plays an important role in controlling progressive motility, in particular average path velocity and linearity. Upon RAC1 inhibition of wild type sperm with...

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Identifiers

PMID: 33539343
DOI: 10.1371/journal.pgen.1009308
PMCID: PMC7861394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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