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Article

Retention of gene products in syncytial spermatids promotes non-Mendelian inheritance as revealed by the t complex responder.

Genes & development - 1 Dec 2009

Véron Nathalie, Bauer Hermann, Weisse Andrea Y, Lüder Gerhild, Werber Martin, Herrmann Bernhard G

Abstract excerpt

The t complex responder (Tcr) encoded by the mouse t haplotype is able to cause phenotypic differences between t and + sperm derived from t/+ males, leading to non-Mendelian inheritance. This capability of Tcr contradicts the concept of phenotypic equivalence proposed for sperm cells, which develop in a syncytium and actively share gene products. By analyzing a Tcr minigene in hemizygous transgenic mice, we show...

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Identifiers

PMID: 19952105
DOI: 10.1101/gad.553009
PMCID: PMC2788329

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Source receipt: pubmed, retrieved 7 Sept 2026.

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