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Article

Advances in the understanding of molecular genetics and therapy of Richter transformation in chronic lymphocytic leukemia.

Leukemia & lymphoma - 1 Dec 2024

Deodato Marina, Frustaci Anna Maria, Zappaterra Arianna, Rapella Alberto, Gambacorti-Passerini Carlo, Cairoli Roberto, Montillo Marco, Tedeschi Alessandra

Abstract excerpt

Richter's transformation (RT) is defined as the evolution of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma. This complication is rare and aggressive, with poor prognosis and dismal survival. Clonal relationship with the underlying CLL/SLL, observed in ∼80% of cases, represents one of the main factors affecting...

Topics

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Biomarkers, Tumor
Cell Transformation, Neoplastic
Disease Management
Disease Progression
Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, Large B-Cell, Diffuse

Molecular Targeted Therapy

Source

Identifiers

PMID: 39219481
DOI: 10.1080/10428194.2024.2398660

Genes

CDKN2A
MYC
NOTCH1
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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