Article
Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in Two TOPMed Cohorts.
American journal of respiratory and critical care medicine - 1 Feb 2022
Kelly Rachel S, Mendez Kevin M, Huang Mengna, Hobbs Brian D, Clish Clary B, Gerszten Robert, Cho Michael H, Wheelock Craig E, McGeachie Michael J, Chu Su H, Celedón Juan C, Weiss Scott T, Lasky-Su Jessica
Abstract excerpt
Rationale: Current guidelines do not sufficiently capture the heterogeneous nature of asthma; a more detailed molecular classification is needed. Metabolomics represents a novel and compelling approach to derive asthma endotypes (i.e., subtypes defined by functional and/or pathobiological mechanisms). Objectives: To validate metabolomic-driven endotypes of asthma and explore their underlying biology. Methods: In...
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