Article

Metabo-Endotypes of Asthma Reveal Clinically Important Differences in Lung Function: Discovery and validation in two TOPMed Cohorts

2021-03-31

Abstract excerpt

<title>Abstract</title> <p>Current guidelines do not sufficiently capture the heterogeneous nature of asthma; a detailed molecular classification is needed. Metabolomics represents a novel and compelling approach to derive asthma endotypes, <italic>i.e.,</italic> subtypes defined by functional/pathobiological mechanisms. In two cohorts of asthmatics, untargeted metabolomic profiling and Similarity Network Fusion...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a3924f7-7cbf-5b5b-8de9-f699f7da8341
DOI: 10.21203/rs.3.rs-358819/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabo-Endotypes of Asthma Reveal Clinically Important Differences in Lung Function: Discovery and validation in two TOPMed CohortsDOI 10.21203/rs.3.rs-358819/v1Read

Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in Two TOPMed Cohorts.Semantic proximity Read

Unraveling heterogeneity and treatment of asthma through integrating multi-omics dataSemantic proximity Read

Childhood asthma in the new omics era: challenges and perspectives.Semantic proximity Read

Multi-Omics Profiling Approach to Asthma: An Evolving ParadigmSemantic proximity Read

Asthma Pathogenesis: Phenotypes, Therapies, and Gaps: Summary of the Aspen Lung Conference 2023Semantic proximity Read

Precision Medicine in Targeted Therapies for Severe Asthma: Is There Any Place for "Omics" Technology?Semantic proximity Read

The Architecture of Deep Phenotyping in Asthma: Integrating Molecular, Metabolic, and Neuro-Hormonal Endotypes.Semantic proximity Read

Omics approaches in asthma research: Challenges and opportunitiesSemantic proximity Read

How variability in clinical phenotypes should guide research into disease mechanisms in asthma.Semantic proximity Read

Are We Meeting the Promise of Endotypes and Precision Medicine in Asthma?Semantic proximity Read

From phenotypes to endotypes to asthma treatment.Semantic proximity Read

What did we learn from multiple omics studies in asthma?Semantic proximity Read