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Article

Identification of the differences in molecular networks between idiopathic pulmonary fibrosis and lung squamous cell carcinoma using machine learning.

Computational biology and chemistry - 1 Dec 2025

Nojima Yosui, Mizuguchi Kenji

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is an independent risk factor for lung cancer, especially squamous cell carcinoma (SCC). The prognosis of patients with both IPF and SCC is poorer than that of patients with only IPF, and preventive measures against SCC in patients with IPF remain elusive. Understanding the distinct mechanisms that induce both diseases is crucial for mitigating SCC onset in patients with IPF....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40580591
DOI: 10.1016/j.compbiolchem.2025.108560

Genes

BHLHE40
DES
E2F4
HOXD11
HPSE2
MYC
PLA2G2A
PRG4
PRUNE2
PZP
S100A7A
SCARA5
STAT1
TMPRSS11B
VCX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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