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Article

PACAP type I receptor activation regulates ECL cells and gastric acid secretion.

The Journal of clinical investigation - 1 Nov 1999

Zeng N, Athmann C, Kang T, Lyu R M, Walsh J H, Ohning G V, Sachs G, Pisegna J R

Abstract excerpt

Pituitary adenylate cyclase activating polypeptide (PACAP) is present in gastric nerves, and PACAP receptors (PAC1) are found on gastric enterochromaffin-like (ECL) cells. Expression of PAC1 splice variants in purified ECL cells was determined by RT-PCR. PACAP effects on ECL cells were analyzed by video imaging of [Ca(2+)](i) and histamine release; its effects on gastric glands were examined by confocal...

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Source

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Identifiers

PMID: 10562300
DOI: 10.1172/JCI7537
PMCID: PMC409843

Genes

VIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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