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Article

Steroids from Ganoderma sinense as new natural inhibitors of cancer-associated mutant IDH1.

Bioorganic chemistry - 1 Sept 2018

Zheng Mengzhu, Tang Ruotian, Deng Yue, Yang Kaiyin, Chen Lixia, Li Hua

Abstract excerpt

Isocitrate dehydrogenase (IDH) is one of the key enzymes in the tricarboxylic acid cycle, and IDH mutations have been associated with many cancers, including glioblastoma, sarcoma, acute myeloid leukemia, etc. Three natural steroids 1-3 from Ganoderma sinense, a unique and rare edible-medicinal fungi in China, were found as potential IDH1 inhibitors by virtual ligand screening method. Among the three compounds, 3...

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Identifiers

PMID: 29738972
DOI: 10.1016/j.bioorg.2018.04.016

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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