Article
Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B.
Acta pharmacologica Sinica - 1 May 2021
Wang Zheng, Li Zeng-Xia, Zhao Wen-Cao, Huang Hong-Bo, Wang Jia-Qi, Zhang Hao, Lu Jun-Yan, Wang Rui-Na, Li Wei, Cheng Zhao, Xu Wen-Long, Di Zhu, Zhou Li-Sha, Jiang Wei, Yu Long, Liu Jun-Yan, Luo Cheng, Zhu Heng, Dan Ye, Pan Wei-Jun, Ju Jian-Hua, Dang Yong-Jun
Abstract excerpt
Grincamycins (GCNs) are a class of angucycline glycosides isolated from actinomycete Streptomyces strains that have potent antitumor activities, but their antitumor mechanisms remain unknown. In this study, we tried to identify the cellular target of grincamycin B (GCN B), one of most dominant and active secondary metabolites, using a combined strategy. We showed that GCN B-selective-induced apoptosis of human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.