Mantle cell lymphomas with concomitant MYC and CCND1 breakpoints are recurrently TdT positive and frequently show high-grade pathological and genetic features.

doi:10.1007/s00428-021-03022-8

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Article

Mantle cell lymphomas with concomitant MYC and CCND1 breakpoints are recurrently TdT positive and frequently show high-grade pathological and genetic features.

Virchows Archiv : an international journal of pathology - 1 Jul 2021

Aukema Sietse M, Croci Giorgio A, Bens Susanne, Oehl-Huber Kathrin, Wagener Rabea, Ott German, Rosenwald Andreas, Kluin Philip M, van den Berg Eva, Bosga-Bouwer Anneke G, Hoogendoorn Mels, Hoster Eva, Bittmann Iris, Nagel Inga, Murga Penas Eva M, Kreuz Markus, Bausinger Julia, Belder Wilfried, Oschlies Ilske, Dyer Martin J S, Jayne Sandrine, Siebert Reiner, Klapper Wolfram

Abstract excerpt

Chromosomal breakpoints involving the MYC gene locus, frequently referred to as MYC rearrangements (MYC - R+), are a diagnostic hallmark of Burkitt lymphoma and recurrent in many other subtypes of B-cell lymphomas including follicular lymphoma, diffuse large B-cell lymphoma and other high-grade B-cell lymphomas and are associated with an aggressive clinical course. In remarkable contrast, in MCL, only few MYC -...

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PMID: 33528622
DOI: 10.1007/s00428-021-03022-8

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