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Mutational Landscape of TdT+ Large B-cell Lymphomas Supports Their Distinction From B-lymphoblastic Neoplasms: A Multiparameter Study of a Rare and Aggressive Entity.

The American journal of surgical pathology - 1 Jan 2022

Bhavsar Shweta, Liu Yen-Chun, Gibson Sarah E, Moore Erika M, Swerdlow Steven H

Abstract excerpt

In the current World Health Organization classification, terminal deoxynucleotidyl transferase (TdT) expression in a high grade/large cell B-cell lymphoma (LBCL) indicates a B-lymphoblastic lymphoma/leukemia (B-LBL), although TdT expression in what appear to be mature LBCL or following mature B-cell neoplasms is reported. The frequency of TdT+ LBCL, how to best categorize these cases, and their clinicopathologic...

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Share to DNA Nucleotidylexotransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Lymphoma, Large B-Cell, Diffuse

Share to Neoplasm Grading

Share to Proto-Oncogene Proteins c-bcl-2

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Identifiers

PMID: 34392269
DOI: 10.1097/PAS.0000000000001750

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