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Article

Gene expression <i>in vivo</i> shows that <i>Helicobacter pylori</i> colonizes an acidic niche on the gastric surface

16 Apr 2007

Abstract excerpt

Helicobacter pylori is a gastric-dwelling pathogen responsible, with acid secretion, for peptic ulcer and a 20-fold increase in the risk of gastric cancer. Several transcriptomes have been described after short-term exposure to acidity in vitro, but there are no data identifying the effects of chronic gastric exposure on bacterial gene expression. Comparison of the in vivo to the in vitro transcriptome at pH 7.4...

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PMID: 17438279
DOI: 10.1073/pnas.0702300104

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