Identification of New Genes Involved in Germline Predisposition to Early-Onset Gastric Cancer.

doi:10.3390/ijms22031310

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Article

Identification of New Genes Involved in Germline Predisposition to Early-Onset Gastric Cancer.

International journal of molecular sciences - 28 Jan 2021

Herrera-Pariente Cristina, Capó-García Roser, Díaz-Gay Marcos, Carballal Sabela, Muñoz Jenifer, Llach Joan, Sánchez Ariadna, Bonjoch Laia, Arnau-Collell Coral, Soares de Lima Yasmin, Golubicki Mariano, Jung Gerhard, Lozano Juan José, Castells Antoni, Balaguer Francesc, Bujanda Luis, Castellví-Bel Sergi, Moreira Leticia

Abstract excerpt

The genetic cause for several families with gastric cancer (GC) aggregation is unclear, with marked relevance in early-onset patients. We aimed to identify new candidate genes involved in GC germline predisposition. Whole-exome sequencing (WES) of germline samples was performed in 20 early-onset GC patients without previous germline mutation identified. WES was also performed in nine tumor samples to analyze the...

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PMID: 33525650
DOI: 10.3390/ijms22031310
PMCID: PMC7866206

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