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Article

Analysis of genomic pathogenesis according to the revised Bethesda guidelines and additional criteria.

Journal of cancer research and clinical oncology - 1 Jan 2021

Kim Jin Cheon, Kim Jong Hwan, Ha Ye Jin, Kim Chan Wook, Tak Ka Hee, Yoon Yong Sik, Kwon Yi Hong, Roh Seon Ae, Cho Dong-Hyung, Kim Seon-Kyu, Kim Seon-Young, Kim Yong Sung

Abstract excerpt

PURPOSE: As few genotype-phenotype correlations are available for nonsyndromic hereditary colorectal cancer (CRC), we implemented genomic analysis on the basis of the revised Bethesda guideline (RBG) and extended (12 items) to verify possible subtypes. METHODS: Patients with sporadic CRC (n = 249) were enrolled, stratified according to the revised Bethesda guidelines (RBG+ and RBG- groups) plus additional...

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PMID: 32960359
DOI: 10.1007/s00432-020-03391-8

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